THE HUDSON PROJECT

NUTRIGENOMICS PATIENT OBSERVATIONAL STUDY

Scientific challenge: reducing oxidative stress in a safe, effective, easy-to-use, and affordable way.”

What is The Hudson Project?

Better ask ‘why’ instead of ‘what’

The Hudson Project is not:

  • a traditional clinical trial
  • not paid for by the pharmaceutical industry
  • not even paid for by the manufacturer of the product that we are using and testing
  • the product is not a registered drug but an FDA regulated nutrigenomics food supplement

The Hudson project is a study designed by a group of enthusiastic collaborating independent souls who are driven by two ideas:

  • helping as many other people and ourselves to life longer healthier
  • cherishing our freedom and independence

Some will call us ‘free radicals’ …. but that is exactly what we are opposed to. We are fighting excessive oxidative stress together and would like to give you the opportunity to join us.

Join us by investing your time and leadership in making a difference for patients.

If you are interested in learning more about oxidative stress, the unique Nrf2 pathway, switching on our ‘survival genes’, making our own antioxidants instead of taking them, and about the possibility giving people an opportunity to let nutrigenomics work for them, then please click the button below.

Erik Sanders, B.Pharm. M.B.A.
Participant in The Hudson Project

Background

oxidative stress

  • our body produces free radicals in all of our cells simply as a byproduct of metabolizing nutrients with oxygen and agents from our environment
  • this phenomenon is called oxidative stress (rusting from the inside out) and causes ‘aging’
  • aging is not simply looking older, but rather becoming more vulnerable to disease
  • aging is not a disease by itself but oxidative stress is linked to more than 200 degenerative diseases

nutrigenomics

  • is research focusing on identifying and understanding molecular-level interaction between nutrients and other dietary bioactives with the genome
  • is a branch of nutritional genomics and is the study of the effects of foods and food constituents on gene expression

DISEASES LINKED TO THE PROCESS OF OXIDATIVE STRESS

Brain

  • Alzheimer’s
  • Parkinson’s
  • Depression
  • ADHD
  • Autism
  • Migraine
  • Stroke
  • Trauma
  • Cancer

Blood vessels

  • Restenosis
  • Atherosclerosis
  • Endothelial dysfunction
  • Hypertension

Lung

  • Asthma
  • COPD
  • Emphysema
  • Allergy
  • ARDS
  • Cancer

Skin

  • Skin aging
  • Sunburn
  • Actinic keratosis
  • Psoriasis
  • Dermatitis
  • Melanoma

Heart

  • CHD
  • Cardiac fibrosis
  • Hypertension
  • Ischemia
  • Myocardial infarction

Immune system

  • Chronic inflammation
  • Autoimmune disorder
  • Lupus
  • IBD
  • MS
  • Cancer

Multi organ

  • Aging
  • Chronic fatique
  • Diabetes

Eye

  • Macular degeneration
  • Retinal degeneration
  • Cateracts

Kidney

  • Chronic kidney disease
  • Renal graft
  • Nephritis

Joints

  • Rheumatoid arthritis
  • Osteoarthritis
  • Psoriasis

MODE OF ACTION

  • first in class nutrigenomics: Nrf2 activator
  • the Nrf2 pathway switches on the body’s survival genes
  • these 500 survival genes stimulate the body’s own production of three proteins: superoxide dismutase, catalase, and glutathione
  • these enzymes scavenge free radical molecules at a rate of up to 1,000,000 per second every second
    (‘traditional’ antioxidants – like vitamin C, vitamin E, carotene, flavonoids, selenium and zinc – do this at a 1:1 ratio)
  • our product solution was developed by making use of Big Data Analysis by the Ingenuity Pathway Analysis® (IPA)* resulting in the optimal combination of 5 effective phytonutrients to stimulate the Nrf2 pathway

* For modeling, analyzing, and understanding complex ‘omics data

• Analysis of gene expression/miRNA/SNP microarray data
• Deeper understanding of metabolomics, proteomics, and RNAseq data
• Identification of upstream regulators
• Insight into molecular and chemical interactions and cellular phenotypes

IPA is an all-in-one, web-based software application that enables analysis, integration, and understanding of data from gene expression, miRNA, and SNP microarrays, as well as metabolomics, proteomics, and RNAseq experiments. IPA can also be used for analysis of small-scale experiments that generate gene and chemical lists. IPA allows searches for targeted information on genes, proteins, chemicals, and drugs, and building of interactive models of experimental systems. Data analysis and search capabilities help in understanding the significance of data, specific targets, or candidate biomarkers in the context of larger biological or chemical systems. The software is backed by the Ingenuity Knowledge Base of highly structured, detail-rich biological and chemical findings.
https://www.qiagen.com/us/products/life-science-research/research-applications/gene-expression-analysis/analysis/ingenuity-pathway-analysis/

“40% reduction oxidative stress after 30 days”

PRODUCT PROFILE

  • reduces oxidative stress caused by lipid peroxidation an average of 40% in 30 days (reductions reported up to 70% in 120 days)
  • protected by 11 international patents
  • currently there are 23 peer reviewed scientific articles published
  • categorized as a nutrigenomic food supplement and not a prescription drug
  • can be used as supportive care aiming for a longer healthier life
  • activates the body to create antioxidants as opposed to consuming them (make vs. take)
  • improves DNA expression

“Nrf2 may well become the most extraordinary therapeutic and most extraordinary preventive breakthrough in the history of medicine**”

Washington State University, 2015

** Pall ML et al., Nrf2, a master regulator of detoxification and also antioxidant, antiinflammatory and other cytoprotective mechanisms,
is raised by health promoting factors, Acta Physiologica Sinica, February 25, 2015, 67(1): 1–18

AVAILABILITY

  • participation in the Hudson Project is exclusively reserved for registered independent medical consultants/distributors
  • qualifying physicians join an elite group of frontrunners of healthcare professionals (currently only 600 of the 1 million doctors certified in the US)
  • shipping, handling, tracking, “back office”, customer support provided
  • fee pay-out of participating practices is based on product volume initiated by the practice (registration via website)

OUR AIM – REAL WORLD DATA

  • in addition to the available scientific publications on oxidative stress (175,000), Nrf2 activation (8,250) and peer reviewed studies (23), our aim is to validate the clinical study results with the ‘real world data’
The projected pay-out fees to participants are based on the number of patients included into the project

STUDY 1:
5 new patients per month

in month 12: approx. $ 5,000
in month 24: approx. $ 10,000

STUDY 2:
include 5 new patients per week

in month 12: approx. $ 23,000
in month 24: approx. $ 82,000

PROJECT PROPOSAL FOR PARTICIPATING PRACTICES

NUMBER OF STUDY CENTERS

  • our local objective is to start with 15 forward thinking independent medical practices in our region for the duration of at least one, but preferably two years

STUDY DESIGN

  • the patient observational study will offer two study goals
    – doctors: baseline and one year (online) data survey
    – patients: baseline and quarterly online survey
  • the study design can be customized to meet the needs and wants of the practice
  • participation will not require extra work by the doctor
  • responsible staff will be trained online by our support team

PRIVACY

  • disclosure of participation in this study is at the practice’s discretion
  • patient data will be reported anonymously

MONTHLY PAY-OUT FEES TO PARTICIPANTS#

  • our local team offers two basic options to participate in this observational study
  • these examples are based on a fixed number of patients each month and a study group of 16 affiliated centers
  • monthly payments will continue as long as the patients continue use of products
  • the pay-out is based on volume initiated by the practice and not on consultancy or research fees
  • all future fees will fall into your estate and are willable

# The earnings of the participants in this proposal are not necessarily representative of the income, if any, that a participant can or will earn through the Product X Compensation Plan. Participants’ success will depend on individual diligence, work effort and number of patients qualifying for the product. Therefore, Product X cannot give any guarantees about the income from this project.

Hi, would you like to know more?
Fill out the form below and I will contact you as soon as possible.

Erik Sanders, BPharm MBA

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