The ingredients in PROTANDIM NRF1 & NRF2 ­support a healthy cell function by improving mitochondrial function and offering proven oxidative stress reduction.

It all starts with the basic processes in our body that use oxygen for burning food to produce energy. This metabolic process takes place in the mitochondria, the “energy factories” of our cells. Like any other production process, it generates harmful by-products. Those by-products accumulate in the cell which results in oxidative stress, which over time will damage the cells and threaten our health.
Aging and 200 diseases are directly linked to the process of oxidative stress. A decrease of oxidative stress will support optimal cell function.

Disclaimer This product is not intended to diagnose, treat, cure, or prevent disease. If you are pregnant or nursing, please consult with your physician before taking Protandim.

Improve your health, start at a cellular level!

Protandim helps the body repair and rejuvenate its own cells and detoxify genes, keeping the master blueprint of the cell’s function intact.





Protandim activates the Nrf2 protein, also known as a “master regulator” of the body’s stress response. Protandim stimulates this protein, resulting in the body producing its own powerful, protective antioxidant enzymes: superoxide dismutase, heme-oxygenase, glutathione peroxidase and catalase.
These enzymes function as potent antioxidants capable of neutralizing more than one million free radicals or reactive oxygen species.

It’s the synergy of plant based ingredients in Protandim that are effective in activating the Nrf2 pathway. There are other benefits of Nrf2 activation beyond cellular protection. Protandim helps the body repair and rejuvenate its own cells and detoxify genes, keeping the master blueprint of the cell’s function intact.

Reduction of oxidative stress

Protandim is the only supplement proven in a clinical study to reduce oxidative stress by an average of
40% in 30 days.

Protandim has been shown to increase superoxide dismutase levels by 30%, glutathione by 300%, and catalase by 54%.

When individuals were supplemented with Protandim for 30 days, the age-dependent increase in lipid peroxidation was completely eliminated. Lipid peroxidation in an older subject was reduced to the level of a 20-year-old. This means the body is not only capable of making its own antioxidant enzymes, but also that their production can be activated by PROTANDIM to reduce cellular stress and may help protect against the aging process and several conditions in which cellular stress has been reported to be a contributing factor.


has been used for 4,000 years in both Ayurvedic and Chinese medicine to help a variety of conditions. Current studies show that turmeric (curcuminoids) helps fight stress, reduce joint discomfort and aid digestion.


has long been hailed for its ability to enhance cognitive abilities. Bacopa has been important in Ayurvedic medicine for centuries, used chiefly to enhance clear thinking and memory function. Studies suggest it provides strong cellular defense. It is also used to improve concentration, alertness and focus (saponins).


called the “King of Ayurvedic herbs,” is an adaptogen (a substance which enhances the resistance of an organism to various stressors) and has been traditionally used as an anxiolytic to help reduce chronic stress. Supports memory enhancement and as a sleep aid. The primary active components are called withanolides.


is made from unfermented leaves and reportedly contains the highest concentration of powerful antioxidants called polyphenols. Protandim’s green tea extract contains 98% polyphenols. Green tea has been traditionally used for many health benefits, including regulating body temperature and blood sugar, promoting digestion, improving mental processes and cardiovascular health.


has been used for 2,000 years as an herbal remedy to support liver, kidney and gallbladder function. Several scientific studies suggest that substances in milk thistle (especially a flavonoid called silymarin) protect the liver from toxins.

The benefits listed for the above ingredients are based on historical/documented use. Some of these benefits may not be available at their full amounts at the current recommended dose of Protandim.

Supplement facts
Serving Size: 1 Caplet Serving per container: 30
Amount Per Serving

% Daily Value

Calcium (as dicalcium phosphate and calcium carbonate) 77 mg 8%*
Proprietary Blend 675 mg†
Milk Thistle Extract (Silybum marianum) seed
Bacopa Extract (Bacopa monnieri) whole herb
Ashwagandha Extract (Withania somnifera) root
Green Tea Extract (Camellia sinensis) leaf
Turmeric Extract (Curcuma longa) rhizome

* % Daily value based on a 2,000 calorie diet.
Daily value not established.

Other ingredients Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Modified Cellulose, Stearic Acid, Magnesium Stearate, Maltodextrin, Medium Chain Triglycerides.

Directions Adults take one caplet with food.

Warnings If you are pregnant, nursing or on immunosuppresive therapy, please consult wiht your physician before taking Protandim.

Note 100% Vegetarian. Free of Gluten, Wheat, Dairy, Gelatin and Yeast.

LifeVantage applied the study of nutrigenomics to identify these natural antioxidants, phytonutrients, and naturally occurring coenzymes to activate Nrf1 and promote mitochondrial growth and function.





Waking up the Nrf1 protein supports:

  • the production of new and larger mitochondria
  • increasing cellular energy (ATP)
  • supports heme production (a building block for hemoglobin)
  • improves cellular repair

Overall your body will function more efficiently


Protandim Nrf1 Synergizer supports mitochondrial function. Combine it with Protandim Nrf2 Synergizer for optimal results!


stimulates the Nrf1 and TFAM pathways, it helps to prevent age-related decreases of mitochondrial biogenesis. Carnitine acts as a transporter of long-chain fatty acids into the mitochondria to be oxidized and produce energy.


is primarily found in mitochondria. It plays an important role in the production of ATP — the source of 95% of your body’s energy. Combined with Alpha Lipioc Acid, it supports cellular energy levels, stress response and antioxidant defense mechanisms.


or ALA, is an antioxidant that helps turn glucose into energy and protects mitochondria by reducing free radicals deep in your cells.


contains powerful natural stilbenoids (resveratrol and viniferin) known to have anti-aging capabilities by activating the Nrf1 protein and other anti-aging pathways.


is a naturally occurring Nrf1 activator that promotes mitochondria production and helps prevent mitochondrial decay.

Supplement facts
Serving Size: 2 capsules Serving per container: 30
Proprietary Blend 455 mg
Acetyl L-Carnitine
Coenzyme Q10
Grape (stem, fruit) Extract
Alpha Lipoic Acid

Daily value not established.

Other ingredients Vegetable Capsule (Non-GMO Plant Cellulose). Non-GMO Rice Flour, Microcrystalline Cellulose, Sucrose Fatty Acid Esters.